Structurally various p-terphenyls with neuraminidase inhibitory from a sponge derived fungus Aspergillus sp. SCSIO41315Article Published on 2023-03-012023-06-23 Journal: Bioorganic chemistry [Category] 신종인플루엔자, [키워드] antiviral effects Aspergillus sp. Neuraminidase inhibitory activity P-Terphenyls Sponge derived fungus. [DOI] 10.1016/j.bioorg.2023.106357 PMC 바로가기
XiaoEr LianHuaQinqGan alleviates viral pneumonia in mice infected by influenza A and respiratory syncytial virusesArticle Published on 2022-12-012023-06-24 Journal: Pharmaceutical Biology [Category] 신종인플루엔자, [키워드] Anti-inflammatory effects antiviral effects immunoregulatory effects. Xiaoer lianhuaqinggan(XELH) [DOI] 10.1080/13880209.2022.2147961 PMC 바로가기
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasionArticle Published on 2022-11-012022-11-15 Journal: Food and chemical toxicology : an international jo [Category] SARS, 변종, 치료제, [키워드] analyzed anti-SARS-CoV-2 antiviral effects binding caused complexes component components demonstrated exhibit FRET test Ganoderma lucidum triterpenoids hACE2 hACE2 receptor high affinity hydrogen bonds IC50 in vitro Infection inhibit inhibited inhibition assay Invasion Lucidenic acid A (PubChem CID: 14109375) molecular docking molecular dynamics Mutation natural natural products omicron Omicron variant omicron variant. pathway Potential Prevent PubChem receptor receptor proteins SARS-CoV-2 Spike protein stability target variant Virtual screening virus was selected were used [DOI] 10.1016/j.fct.2022.113438 PMC 바로가기
Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2SARS-CoV-2 Omicron subvariants, BA.1 및 BA.2에 대한 중화 항체 및 항바이러스 약물의 다양한 효능Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analysis Analysis antibodies antibody Antiviral antiviral drug antiviral drugs Antiviral effect antiviral effects BA.1 BA.2 Casirivimab Cell culture concentrations conserved coronavirus Delta drug treatment Efficacy EIDD-1931 Evidence FIVE Gamma Imdevimab Infection intrinsic mathematical molnupiravir Neutralizing antibodies neutralizing antibody Nirmatrelvir omicron other variant other variants quantified replacing respiratory SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus Sotrovimab Sotrovimab. Spread Treatment variant variants Viral [DOI] 10.1016/j.antiviral.2022.105372 PMC 바로가기 [Article Type] Article
Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19Article Published on 2022-09-012022-11-15 Journal: American journal of physiology. Lung cellular and [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ACE2 addition airway alveolar angiotensin-converting enzyme 2 anti-inflammatory effect Anti-inflammatory effects anti-inflammatory property antioxidant Antiviral Antiviral effect antiviral effects binding cell entry cleavage cleave Concentration COVID-19 cysteamine decrease determine disrupt drug drugs Effect effective functional hamster hemorrhage in vivo infected with SARS-CoV-2 Inflammation inhibit Injury intraperitoneally limit lung Lung inflammation Lung injury mechanism neutrophilic oxidative stress pseudovirus redox status reporter SARS-2-S SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike glycoprotein SARS-CoV-2 viruses significantly tested thiol drugs. thiol group viral infection virus infection [DOI] 10.1152/ajplung.00136.2022 PMC 바로가기
Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study항바이러스제를 광범위하게 사용하면 COVID-19 전염병을 억제할 수 있습니까? 모델링 연구Article Published on 2022-08-092022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 치료제, [키워드] age agent agent-based model analyzed Antiviral antiviral drug antiviral drugs Antiviral effect antiviral effects Antiviral treatment antiviral treatments Belgium Combination country COVID-19 COVID-19 disease COVID-19 hospitalization death deaths disease effective Effective vaccines help highlight Hospitalization inception Increases Infection Kenya location majority mathematical mathematical model mitigate Mortality Older populations Prevent prevented progression reduce reduced reducing Safe SARS-CoV-2 SARS-CoV-2 transmission SARS-CoV-2. shown significantly symptomatic symptomatic infection symptoms onset synergistic synergistic effect Transmission Treatment treatment initiation treatments for COVID-19 United State United States vaccination vaccination rate widespread [DOI] 10.1186/s12879-022-07639-1 PMC 바로가기 [Article Type] Article
Low molecular weight chitooligosaccharide inhibits infection of SARS-CoV-2 in vitro저분자량 키토올리고당은 시험관 내에서 SARS-CoV-2의 감염을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Journal of Applied Microbiology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Analysis Antiviral Antiviral effect antiviral effects candidate chitooligosaccharide chitosan COVID-19 cytotoxicity dose-dependent manner Drug development E gene fluorescence intensity gel in vitro infected cells Infection inhibit low molecular weight molecular weight MTT natural antiviral natural treatment. permeation Plaque assay Protein Quantitative RdRP respond SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 virus Significance suggested tested the SARS-CoV-2 virus Treatment Vero cells Viral RNA virus-infected cell virus-infected cells was measured [DOI] 10.1111/jam.15618 PMC 바로가기 [Article Type] Article
The global succinylation of SARS-CoV-2-infected host cells reveals drug targetsSARS-CoV-2에 감염된 숙주 세포의 세계적인 숙시닐화는 약물 표적을 드러낸다Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Analysis Antiviral antiviral drug antiviral drug target antiviral effects antiviral therapies Caco-2 Caco-2 cells causative agent cellular cellular pathway cellular pathways conserved COVID-19 COVID-19 pandemic demonstrated drug target enzyme Evolution highlighting Host host cell host protein inhibit inhibitor Interaction mechanism membrane protein Membrane proteins metabolic pathways Modification nsp14 overexpressed promote Protein Quantitative regulated Regulatory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SIRT5 sirtuin succinylproteomics. variants Viral proteins virus replication [DOI] 10.1073/pnas.2123065119 PMC 바로가기 [Article Type] Article
Characterizing SARS-CoV-2 Viral Clearance Kinetics to Improve the Design of Antiviral Pharmacometric StudiesSARS-CoV-2 바이러스 제거 동역학 특성화를 통해 항바이러스 약리학적 연구 설계 개선Article Published on 2022-07-192022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] analyzed Antiviral antiviral drug antiviral drugs antiviral effects antiviral treatments assessment clearance clearance rate clinical trials conducted Consensus COVID-19 illness Effect estimate exponential decay model individuals Infection Kinetics methodology Metrics molnupiravir Nasopharyngeal swab Nasopharyngeal swab samples Nirmatrelvir Patient Pharmacodynamics Phase 2 profile provide qPCR randomized trial randomized trials reduced reported robust Sample size sample sizes SARS-CoV-2 splines Statistical power time to clearance. Trial viral clearance Viral load virological response [DOI] 10.1128/aac.00192-22 PMC 바로가기 [Article Type] Article